• Login
    View Item 
    •   AUW IR
    • Faculty Research
    • Science & Math
    • Current Faculties
    • Ayan Roy
    • Articles
    • 2022
    • View Item
    •   AUW IR
    • Faculty Research
    • Science & Math
    • Current Faculties
    • Ayan Roy
    • Articles
    • 2022
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    Thumbnail
    View/Open
    2022 (3).pdf (3.214Mb)
    Date
    2022
    Author
    Roy, Ayan
    Metadata
    Show full item record
    Abstract
    Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debil- itating disease characterized by unexplained physical fatigue, cognitive and sensory dysfunction, sleeping disturbances, orthostatic intolerance, and gastrointestinal problems. People with ME/CFS often report a prodrome consistent with infections. Using regression, Bayesian and enrichment analyses, we conducted targeted and untargeted metabolomic analysis of plasma from 106 ME/CFS cases and 91 frequency-matched healthy controls. Subjects in the ME/CFS group had significantly de- creased levels of plasmalogens and phospholipid ethers (p < 0.001), phosphatidylcholines (p < 0.001) and sphingomyelins (p < 0.001), and elevated levels of dicarboxylic acids (p = 0.013). Using machine learning algorithms, we were able to differentiate ME/CFS or subgroups of ME/CFS from controls with area under the receiver operating characteristic curve (AUC) values up to 0.873. Our findings provide the first metabolomic evidence of peroxisomal dysfunction, and are consistent with dys- regulation of lipid remodeling and the tricarboxylic acid cycle. These findings, if validated in other cohorts, could provide new insights into the pathogenesis of ME/CFS and highlight the potential use of the plasma metabolome as a source of biomarkers for the disease.
    URI
    repository.auw.edu.bd:8080//handle/123456789/810
    Collections
    • 2022 [9]

    DSpace software copyright © 2002-2022  LYRASIS
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of AUW Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2022  LYRASIS
    Contact Us | Send Feedback
    Theme by 
    Atmire NV